منابع مشابه
Autophagy and innate immunity.
munity-related GTPase M) and NOD2 (nucleotide-binding oligomerization domain 2)] results in the development of immune-related diseases, such as Crohn’s disease, a chronic inflammatory bowel disease [2] . Autophagy represents an ancient immune defense strategy present in flies. Importantly, as flies lack an adaptive immune system, the function of autophagy in cellintrinsic innate immunity can be...
متن کاملAutophagy in Innate Recognition of Pathogens and Adaptive Immunity
Autophagy is a specialized cellular pathway involved in maintaining homeostasis by degrading long-lived cellular proteins and organelles. Recent studies have demonstrated that autophagy is utilized by immune systems to protect host cells from invading pathogens and regulate uncontrolled immune responses. During pathogen recognition, induction of autophagy by pattern recognition receptors leads ...
متن کاملBacterial Invasion: Linking Autophagy and Innate Immunity
Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity and autophagy.
متن کاملPathogen-induced autophagy signaling in innate immunity.
Innate immunity induces rapid responses to fight invading pathogens. To eliminate intracellular bacteria or viruses, innate cellular responses lead to the production of nuclear factor-κB-dependent inflammatory cytokines, inflammasome activation, type I interferon synthesis, and/or eventually death of the infected cells. Autophagy emerged as another component of innate immunity, as it offers an ...
متن کاملVirus-Induced Autophagy in Innate Immunity
When a virus invades a host cell, autophagy is triggered to maintain cellular homeostasis. Virus-induced autophagy is a double-edged sword in the antiviral function of host innate immunity. Unlike apoptosis, autophagy plays a different role in cell survival or inducing cell death. This mini-review summarizes recent developments in our understanding of the antiviral roles of autophagy in host in...
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ژورنال
عنوان ژورنال: Proceedings of the American Thoracic Society
سال: 2010
ISSN: 1546-3222
DOI: 10.1513/pats.200909-103js